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Showing 1 to 12 of 289 entries
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A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia.

Leukemia research reports

Toft-Petersen M, Kjeldsen E, Nederby L, Grønbæk K, Hokland P, Roug AS.
PMID: 25473623
Leuk Res Rep. 2014 Nov 13;3(2):94-7. doi: 10.1016/j.lrr.2014.09.002. eCollection 2014.

We have identified a novel 7.7 Mb del(8)(q23.2q24.11) in a patient progressing to acute myeloid leukemia (AML) following a 12-year stable phase of chronic myelomonocytic leukemia (CMML). A surprisingly high JAK2+ allelic burden of 92% at the time of...

Four hepatosplenic T-cell lymphoma cases of Japanese patients.

Leukemia research reports

Kawai H, Matsushita H, Ohmachi K, Kojima M, Machida S, Ogawa Y, Kawada H, Nakamura N, Ando K.
PMID: 26870659
Leuk Res Rep. 2015 Dec 15;5:3-6. doi: 10.1016/j.lrr.2015.12.001. eCollection 2016.

Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein report 4 Japanese...

Kinetics of del(7q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm.

Leukemia research reports

Herborg LL, Nederby L, Kjeldsen E, Grønbæk K, Hokland P, Hansen M, Celik Hansen M, Roug AS.
PMID: 24371780
Leuk Res Rep. 2013 Jul 04;2(2):51-3. doi: 10.1016/j.lrr.2013.06.001. eCollection 2013.

Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated...

Short communications and case reports-Who cares?.

Leukemia research reports

Mundle S, Wetzler M.
PMID: 24371762
Leuk Res Rep. 2012 Nov 21;1(1):A1. doi: 10.1016/j.lrr.2012.11.001. eCollection 2012.

No abstract available.

The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine.

Leukemia research reports

Al Ustwani O, Greene JD, Wetzler M.
PMID: 24371774
Leuk Res Rep. 2013 Apr 30;2(1):34-5. doi: 10.1016/j.lrr.2013.03.002. eCollection 2013.

Patients with myelodysplastic syndrome who fail hypomethylating agents have a very short median survival and about 25% risk of disease transformation to acute myeloid leukemia. We report our experience with low-dose protracted oral clofarabine in one patient who achieved...

Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia.

Leukemia research reports

Purev E, Dumitriu B, Hourigan CS, Young NS, Townsley DM.
PMID: 25003026
Leuk Res Rep. 2014 Jun 11;3(2):46-8. doi: 10.1016/j.lrr.2014.04.002. eCollection 2014.

We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic...

Extracellular crystals in plasma cell myeloma.

Leukemia research reports

Brown JT, Burack WR, Becker MW, Vlad-Vonica R, Nadasdy T, Bennett JM, Mendler JH.
PMID: 25003027
Leuk Res Rep. 2014 Jun 18;3(2):49-50. doi: 10.1016/j.lrr.2014.04.004. eCollection 2014.

No abstract available.

Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells.

Leukemia research reports

Federzoni EA, Gloor S, Jin J, Shan-Krauer D, Fey MF, Torbett BE, Tschan MP.
PMID: 25984443
Leuk Res Rep. 2015 Apr 23;4(1):32-5. doi: 10.1016/j.lrr.2015.04.002. eCollection 2015.

In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that...

A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia.

Leukemia research reports

Yao J, Douer D, Wang L, Arcila ME, Nafa K, Chiu A.
PMID: 28275539
Leuk Res Rep. 2017 Jan 31;7:17-19. doi: 10.1016/j.lrr.2017.01.003. eCollection 2017.

Philadelphia (Ph) chromosome is a cytogenetic hallmark of chronic myeloid leukemia (CML). Most patients with CML harbor either the e13a2 or e14a2 BCR-ABL fusion product, while a small subset of the cases expresses e1a2 or e19a2 transcripts. We report...

A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia.

Leukemia research reports

Hossain A, Rafei H, Jariwala A, El-Shami K.
PMID: 28275540
Leuk Res Rep. 2017 Jan 24;7:20-22. doi: 10.1016/j.lrr.2017.01.001. eCollection 2017.

The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (

Aspirin and risk of multiple myeloma in adults: A systematic review and meta-analysis.

Leukemia research reports

Lee SF, Ng TY, Wong FC, Tung SY.
PMID: 28331798
Leuk Res Rep. 2017 Feb 28;7:23-28. doi: 10.1016/j.lrr.2017.02.002. eCollection 2017.

Multiple myeloma is a relatively uncommon plasma cell malignancy. Preclinical and clinical studies have suggested that aspirin might modify the risk of multiple myeloma. We performed a systematic review and meta-analysis of studies to examine the association between regular...

Cardiac anaplastic large cell lymphoma in an 8-year old boy.

Leukemia research reports

Lauten M, Vieth S, Hart C, Wössmann W, Tröger B, Härtel C, Bethge M, Schrauder A, Cario G.
PMID: 24918065
Leuk Res Rep. 2014 May 15;3(2):36-7. doi: 10.1016/j.lrr.2014.05.001. eCollection 2014.

We report on an 8 year old boy with primary cardiac anaplastic large cell lymphoma (ALCL), in whom the diagnosis was challenging and who was treated with modified chemotherapy without radiation therapy according to the ALCL 99 study protocol...

Showing 1 to 12 of 289 entries